Target Safety Assessment (TSA) reporting
Target-related toxicity accounts for approximately half of drug failures due to safety reasons. The TSA therefore forms an integral role in the toxicology programme by guiding the assessment and mitigation of target-related toxicities.
The Phenotox TSA is expert toxicologist generated and based on the widest possible target data profile to provide optimal insight into potential target-related toxicities and their mitigation.
The Phenotox TSA can also be used for assessing off-target toxicities of candidate drugs and for molecular initiating events associated with adverse outcome pathways caused by agrochemicals, consumer health chemicals and cosmetics.
Molecular Toxicology Consultancy
Molecular toxicology approaches are used to design in vitro screens for common drug toxicities (e.g. organ-specific toxicity), identify safety biomarkers and to determine mechanisms of toxicity. Many of these approaches have been developed in the drug discovery industry and now have utiltility to the wider chemical safety sector.
We have a wealth of experience in Molecular Toxicology that is relevant for drug discovery, drug development and across the chemical safety sector.
Innovative Toxicology Development
We offer a range of services for development of innovative toxicology technologies with a strong track record of working with service providers, academia and industry.